Psychiatric Disturbances

Social Deficits, Social withdrawal
Mercury

Repetitive, preseverative, stereotyped behaviors; OCD-typical behaviors
Mercury

Depression, mood swings, flat affect; impaired facial ecognition
Arsenic, Copper, Lead, Mercury

Schizoid tendencies; hallucinations; delirium
Mercury

Irritability, aggressive behaviors, temper tantrums
Lead, Mercury

Suicidal Behaviors
Copper, Mercury

Sleep difficulties/ disturbances
Lead, Mercury, Thallium

Chronic fatigue (CFS); weakness, malaise
Aluminum, Arsenic, Cadmium, Copper, Lead, Mercury, Thallium

Anorexia; symptoms reflecting eating disorders; loss of appetite/weight
Arsenic, Lead, Mercury

Anxiety; nervous tendencies
Thallium

Attention problems (ADHD), lacks eye contact, impaired visual fixation
Lead, Mercury

Speech and Language Deficits

Speech disorders
Aluminum, Mercury

Loss of speech, developmental problems with language
Mercury

Speech comprehension deficits
Mercury

Dysarthria articulation problems slurred speech, unintelligible speech
Mercury

Cognitive Impairments

Mental retardation, borderline intelligence
Arsenic, Lead, Mercury

Uneven performance on IQ scores, low IQ scores
Copper, Lead

Poor concentration, attention deficits (ADHD), response inhibition
Aluminum, Lead

Poor memory (short term, verbal and auditory)
Aluminum, Lead

Dementia; pre-senile and senile dementia
Aluminum

Stupor
Aluminum, Arsenic

Sensory Abnormalities

Abnormal Sensations in the mouth and extremities
Arsenic

Hearing loss, difficulty hearing
Arsenic, Lead, Mercury

Abnormal touch sensations; diminished touch sensations, aversion to touch
Arsenic

Blurred vision; sensitivity to light
Arsenic, Mercury

Choreiform movements, myoclonal jerks, unusual postures
Copper, Mercury

Difficulty walking, swallowing talking
Copper, Mercury

Flapping, circling, rocking, toe walking
Mercury

Problems with intentional movements or imitation
Mercury

Abnormal gait/posture; incoordination, loss of balance;
problems sitting, lying, crawling, and walking
Mercury

Decreased locomotor activity
Aluminum, Arsenic

Convulsions; seizure
Aluminum, Arsenic, Copper, Lead, Mercury, Thallium

Physiological Impairment

Brain and Central Nervous System

Neurofibrillary tangles
Aluminum

Neuritis, retrobulbar neuritis; neuropathy
Aluminum, Arsenic, Thallium

Encephalopathy
Aluminum, Arsenic, Lead, Thallium

Alterations in nerve conduction velocity
Lead

Alterations in the spinal chord
Thallium

Accumulates in CNS structures
Aluminum, Mercury

Autonomic disturbances
Copper, Lead,Mercury, Thallium

Peripheral Nervous System

Peripheral neuropathy
Arsenic, Mercury

Alterations in peripheral nerves
Arsenic

Loss of feeling/ numbness in the extremities
paresthesia
Arsenic, Mercury, Thallium

Gastrointestinal Tract

Nausea, vomiting, diarrhea; loss of appetite
Arsenic, Copper, Mercury, Thallium

Abdominal pain, stomach cramps; burning of the throat and mouth
Arsenic, Copper, Lead, Mercury, Thallium

Esophagitis; gastroenteritis; colitis
Arsenic, Mercury, Thallium

Cancers (colon, pancreatic, stomach, or rectal)
Arsenic

Hepatotoxicity; Liver; dysfunction damage
Arsenic, Copper, Thallium

Kidney disease; kidney failure
Arsenic, Lead, Mercury

Renal toxicity; tubular proteinosis
Arsenic, Copper, Lead

Kidney Damage, histological alterations
Arsenic, Lead

Cardiovascular System

Blood vessel damage
Arsenic

Anemia decreased red blood cell count
Arsenic, Copper, Lead

Hypertension increased heart rate (tachycardia)
Arsenic, Copper, Lead, Thallium

Electrocardiac disorders

Peripheral vascular disease cardiovascular disease vascular collapse
Arsenic, Lead

Respiratory System

Pulmonary Fibrosis
Aluminum, Arsenic

Pneumonia, laryngitis, pharyngitis, bronchitis
Aluminum, Arsenic, Mercury

Restrictive airway disorders, asthmatic conditions, pneumoconiosis
Arsenic, Aluminum

Respiratory tract cancers
Arsenic

Immune System

Immuno suppression
Lead

Decreased white blood cell count
Arsenic, Thallium

Reproductive System

Genital abnormalities
Aluminum, Thallium

Disturbances in menstrual cycle menstrual pains
Copper, Mercury

Birth defects premature births Spontaneous abortion
Arsenic, Lead, Mercury

Reproductive dysfunction
Arsenic, Aluminum, Cadmium, Lead

Rashes, contact dermatitis, eczema, itchy/irritating skin
Aluminum, Arsenic, Copper, Mercury

Muscle pain; headache; acrodynia; colic
Arsenic, Copper, Lead, Thallium